Publications
Selected Publications
Mark Dombrovski, Yixin Zang, Giovanni Frighetto, Andrea Vaccari, HyoJong Jang, Parmis S. Mirshahidi, Fangming Xie, Piero Sanfilippo, Bryce W. Hina, Aadil Rehan, Roni H. Hussein, Pegah S. Mirshahidi, Catherine Lee, Aileen Morris, Mark A. Frye, Catherine R. von Reyn, Yerbol Z. Kurmangaliyev, Gwyneth M. Card & S. Lawrence Zipursky
Nature 644, 453–462 (2025).
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Nature 644, 453–462 (2025).
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We discover a new molecular principle of synaptic specificity (i.e., precise brain wiring), where levels of gene expression within a single neuronal type can fine-tune synapse numbers, enabling precise wiring
of ethologically relevant neural circuits.
of ethologically relevant neural circuits.
Mark Dombrovski, Martin Y. Peek, Jin-Yong Park, Andrea Vaccari, Marissa Sumathipala, Carmen Morrow, Patrick Breads, Arthur Zhao, Yerbol Z. Kurmangaliyev, Piero Sanfilippo, Aadil Rehan, Jason Polsky, Shada Alghailani, Emily Tenshaw, Shigehiro Namiki, S. Lawrence Zipursky & Gwyneth M. Card
Nature 613, 534–542 (2023).
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Nature 613, 534–542 (2023).
Pubmed Read PDF
We discover a new principle of neuronal connectivity, where synapse numbers gradually vary between neurons belonging
to the same neuronal type. This enables accurate and precise transformation of object location into precise movement directions.
to the same neuronal type. This enables accurate and precise transformation of object location into precise movement directions.
Other Publications
Electrical Synapses Mediate Visual Approach Behavior
Frighetto, G., Dombrovski, M., Kurmangaliyev, Y.Z., Zipursky, S.L. and Frye, M.A. bioRxiv (2025).
A Connectome and Transcriptome Identity Switch through a Single Transcription Factor Isoform
Smolin, N., Dombrovski, M., … J., Kurmangaliyev, Y. and von Reyn, C.R. bioRxiv.(2025)
Brain Wiring Determinants Uncovered by Integrating Connectomes and Transcriptomes
Yoo, J., Dombrovski, M., … Zipursky, S.L. and Kurmangaliyev, Y.Z., 2023. Current Biology. (2023).
FlySeg: an Automated Volumetric Instance Segmentation Algorithm for Dense Cell Populations in Drosophila Melanogaster Nervous System
Vaccari, A. and Dombrovski, M. Proceedings of the IEEE. (2023).
Critical Periods Shaping the Social Brain: A Perspective from Drosophila
Dombrovski, M. and Condron, B.BioEssays. (2021).
Cooperative Foraging During Larval Stage Affects Fitness in Drosophila
Dombrovski, M., Kuhar, R., Mitchell, A., Shelton, H. and Condron, B. J Comp Phys A. (2020).
A Plastic Visual Pathway Regulates Cooperative Behavior in Drosophila Larvae
Dombrovski, M., Kim, A., … Condron, B., and Yuan, Q. Current Biology. (2019).
Cooperative Behavior Emerges Among Drosophila Larvae
Dombrovski, M., Poussard, L., …. Acton, S. and Condron, B. Current Biology. (2017).
Frighetto, G., Dombrovski, M., Kurmangaliyev, Y.Z., Zipursky, S.L. and Frye, M.A. bioRxiv (2025).
A Connectome and Transcriptome Identity Switch through a Single Transcription Factor Isoform
Smolin, N., Dombrovski, M., … J., Kurmangaliyev, Y. and von Reyn, C.R. bioRxiv.(2025)
Brain Wiring Determinants Uncovered by Integrating Connectomes and Transcriptomes
Yoo, J., Dombrovski, M., … Zipursky, S.L. and Kurmangaliyev, Y.Z., 2023. Current Biology. (2023).
FlySeg: an Automated Volumetric Instance Segmentation Algorithm for Dense Cell Populations in Drosophila Melanogaster Nervous System
Vaccari, A. and Dombrovski, M. Proceedings of the IEEE. (2023).
Critical Periods Shaping the Social Brain: A Perspective from Drosophila
Dombrovski, M. and Condron, B.BioEssays. (2021).
Cooperative Foraging During Larval Stage Affects Fitness in Drosophila
Dombrovski, M., Kuhar, R., Mitchell, A., Shelton, H. and Condron, B. J Comp Phys A. (2020).
A Plastic Visual Pathway Regulates Cooperative Behavior in Drosophila Larvae
Dombrovski, M., Kim, A., … Condron, B., and Yuan, Q. Current Biology. (2019).
Cooperative Behavior Emerges Among Drosophila Larvae
Dombrovski, M., Poussard, L., …. Acton, S. and Condron, B. Current Biology. (2017).
